Ca 2+ ‐activated K + channel K Ca 1.1 as a therapeutic target to overcome chemoresistance in three‐dimensional sarcoma spheroid models
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چکیده
منابع مشابه
Intermediate-Conductance Ca -Activated K Channel, KCa3.1, as a Novel Therapeutic Target for Benign Prostatic Hyperplasia
Recently, a new experimental stromal hyperplasia animal model corresponding to clinical benign prostatic hyperplasia (BPH) was established. The main objective of this study was to elucidate the roles of the intermediate-conductance Ca -activated K channel (KCa3.1) in the implanted urogenital sinus (UGS) of stromal hyperplasia BPH model rats. Using DNA microarray, real-time polymerase chain reac...
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We have isolated a K(+)-selective, Ca(2+)-dependent whole cell current and single-channel correlate in the human erythroleukemia (HEL) cell line. The whole cell current was inhibited by the intermediate-conductance KCa3.1 inhibitors clotrimazole, TRAM-34, and charybdotoxin, unaffected by the small-conductance KCa2 family inhibitor apamin and the large-conductance KCa1.1 inhibitors paxilline and...
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Cytoskeletal proteins are known to sculpt the structural architecture of cells. However, their role as bridges linking the functional crosstalk of different ion channels is unknown. Here, we demonstrate that a small conductance Ca -activated K channels (SK2 channel), present in a variety of cells, where they integrate changes in intracellular Ca concentration [Ca i] with changes in K conductanc...
متن کاملAllosteric Gating of a Large Conductance Ca-activated K+ Channel
Large-conductance Ca-activated potassium channels (BK channels) are uniquely sensitive to both membrane potential and intracellular Ca2+. Recent work has demonstrated that in the gating of these channels there are voltage-sensitive steps that are separate from Ca2+ binding steps. Based on this result and the macroscopic steady state and kinetic properties of the cloned BK channel mslo, we have ...
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STIM1 'senses' decreases in endoplasmic reticular (ER) luminal Ca(2+) and induces store-operated Ca(2+) (SOC) entry through plasma membrane Orai channels. The Ca(2+)/calmodulin-activated K(+) channel K(Ca)3.1 (previously known as SK4) has been implicated as an 'amplifier' of the Ca(2+)-release activated Ca(2+) (CRAC) current, especially in T lymphocytes. We have previously shown that human macr...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2021
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.15046